Police are appealing for witnesses or anyone with dashcam footage to contact officers following a collision on the M6 today (April 17).
It happened on the southbound carriageway, between junctions 38 and 37, at about 3.40am.
It involved a white Scania lorry towing a Morrisons liveried trailer and a red Toyota IQ.
The driver of the lorry was uninjured.
The driver of the Toyota, a woman in her forties, was taken to Royal Preston Hospital with serious injuries.
The M6 remained closed for several hours while investigations took place and the scene cleared.
Police are appealing for any motorists who may have seen either vehicle this morning to come forward.
Officers are also asking for anyone who was in the area at the time with a dashcam to contact them on 101, referring to incident 42 – or email SCIU@cumbria.police.uk